A member asked:

What is sporadic fatal insomnia? what are the sign and symptoms of it?

7 doctors weighed in across 2 answers
Dr. Pamela Pappas answered

Specializes in Psychiatry

SFI: Sporadic fatal insomnia is a very rare, transmissible neurodegenerative disease characterized by the accumulation of a misfolded protein (the prion protein) in the brain. Symptoms include disrupted sleep, autonomic dysfunction, and motor abnormalities including myoclonus, ataxia, dysarthria, dysphagia, and pyramidal signs like clonus on exam. There may be peculiar behaviors too.

Answered 12/3/2015

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Dr. Alan Ali answered

Specializes in Psychiatry

SFI: Only 8 cases have ever been diagnosed as of july 2005, so it is extremely rare.

Answered 1/20/2016

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Can a hanging eyelid be a symptom of sporadic fatal insomnia?

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