A member asked:

How soon does benadryl (diphenhydramine) kick in after taking it?

A doctor has provided 1 answer
Dr. Michael Zacharisen answered

Specializes in Allergy and Immunology

15-30 minutes: The onset of action following oral administration occurs in 15 to 30 minutes, with peak concentrations occurring in about 2 to 4 hours.

Answered 9/11/2013

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