No: When taken at recommended doses there are no cumulative adverse effects from the long-term use of Diphenhydramine (benadryl) or any other commonly used antihistamine.
Answered 10/13/2017
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Generally no...: However Benadryl (diphenhydramine) does have side effects, one of which is drowsiness. If subtle, this can cause poor school performance for example.Another side effect can be hyperactivity or overstimulation which may effect performance. So be careful.
Answered 12/9/2015
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