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A 21-year-old member asked:

What is iron overload, hemochromatosis?

2 doctor answers3 doctors weighed in
Dr. Jason Hemming
Gastroenterology 18 years experience
Too much bodily iron: As a result of the inability to increase iron loss, iron overload is an inevitable response to increased iron entry into the body. This can occur by one of three mechanisms - nutritional intake, increased absorption, parenteral sources (i.e. Transfusions). Hemochromatosis is abnormally high absorption of iron as result of a genetic defect. Extra iron can be toxic.
Dr. ASHRAF MALEK
Specializes in Hepatology
Iron overload: Iron overload are the diseases that cause excess accumulation of iron on various organs and in the long run cause serious damage to those organs. The most common organ involved is the liver. There are inherited diseases, which cause excess iron in the liver mostly, and less commonly in other organs, such as heart, pancreas, skin etc. There are diseases, which called secondary hemochromatosis.

Similar questions

A 22-year-old member asked:

How common is iron overload/hemochromatosis?

2 doctor answers3 doctors weighed in
Dr. Jason Hemming
Gastroenterology 18 years experience
Hard to say: It is impossible to say as there are many causes for iron overlaid and even hhc. For the common c282y homozygotes it has been approximated to be 0.44% in caucasian populations.
A 21-year-old member asked:

Who is affected by iron overload/hemochromatosis?

2 doctor answers3 doctors weighed in
Dr. Jason Hemming
Gastroenterology 18 years experience
C282Y Homozygous: Most commonly seen in those with 2 copies of the c282y genetic mutation of the hfe gene. However there are other defects that may result in hhc. Hemochromatosis may result in iron overload, however not all iron overload is from hemochromatosis.
A 21-year-old member asked:

What are the symptoms of iron overload, hemochromatosis?

2 doctor answers5 doctors weighed in
Dr. Robert Kwok
Pediatrics 34 years experience
Fatigue, aches: A person absorbs iron from foods and oral iron supplements because human bodies require iron. If he has plenty of iron, his body won't absorb as much iron, but he will not stop absorbing iron. That means he can get iron overload by taking too high a dose of iron supplements. Iron overload damages the liver, and causes symptoms of fatigue, weakness, joint pains, abdominal pains, etc...
A 22-year-old member asked:

How serious is iron overload, hemochromatosis?

3 doctor answers10 doctors weighed in
Dr. Maritza Baez
Family Medicine 18 years experience
Can be deadly: Over time, excesses of iron build up in major organs such as the heart, liver, pancreas, joints and pituitary. If the extra iron is not removed, these organs can become diseased, causing conditions like diabetes mellitus, irregular heart beat or heart attack, arthritis, cirrhosis of the liver or liver cancer, gall bladder disease, depression, impotence, infertility, hypothyroidism, hypogonadism.
A 22-year-old member asked:

How is a diagnosis for iron overload/hemochromatosis confirmed?

2 doctor answers6 doctors weighed in
Dr. Jason Hemming
Gastroenterology 18 years experience
Labs and Bx: Labs that include ferritin and transferrin saturation. All patients being evaluated for hhc should have c282y and h63d mutation analysis. This may help in determine risk for hhc but is not always diagnostic by itself. Lastly a liver biopsy with a iron index or MRI may help to confirm suspected cases.
Last updated Nov 16, 2019

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