Can you get serotonin syndrome from long term zoloft (sertraline) use?

Combo or high dose: Serotonin syndrome is too much serotonin in the brain. If you have tolerated zoloft (sertraline) for a long time, than your chances of developing the syndrome are low, unless your dose was increased or another med added. Other psychotropics, pain meds (e.g. Ultram), migraine meds (triptans), HIV meds, stimulants & hallucinogens w/ zoloft (sertraline) can raise the risk. Inform your doctor of all the meds you're taking.