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A member asked:

Are fexofenadine hcl and diphenhydramine hcl the same?

A doctor has provided 1 answer

No: Benadryl (diphenhydramine) is a short-acting antihistamine and is more likely to make you sleepy when used. Fexofenadine is a second-generation, non-sedating antihistamine which should have more lasting effects, closer to 24 hours, and is less likely to make you sleepy.

Dr Parvez agreed

Answered 6/5/2019

4.9k views

Thank

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What should I take diphenhydramine HCl 25mg or diphenhydramine citrate 38mg?

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I've been taking about 500 to 1400mg of OTC diphenhydramine hcl daily for about the last 6-8 years and have stopped. How can I stop the ITCHING!!?

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Been taking diphenhydramine HCL for about 10 years in high doses. I have recently stopped taking them. The itching is intense. HOW CAN I STOP THE ITCH?

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