A 45-year-old member asked:
Are fexofenadine HCl and diphenhydramine HCl the same?
1 doctor answer
Dr. John Norvell answered
20 years experience in Allergy and Immunology
No: Benadryl (diphenhydramine) is a short-acting antihistamine and is more likely to make you sleepy when used. Fexofenadine is a second-generation, non-sedating antihistamine which should have more lasting effects, closer to 24 hours, and is less likely to make you sleepy.
Answered on Jun 5, 2019
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