Are there any base-line protocols for testing that are recommended for all types of eds?

Yes: Careful family history, physical exam, echocardiogram if indicated, skin biopsy for collagen typing, collagen gene mutation testing and lysyl hydroxylase or lysyl oxidase activity.

Yes.: Both clinical exam and genetic testing needed.. A good pediatrician or geneticist are most likely to diagnose this, since presentation is early. I personally would see a geneticist if this diagnosis is in question. The hypermobility of joints leads to accelerated arthritis, ie. Osteoarthritis, and sprains.