How long does it take for oxycodone to be used up in the body?

Oxycodone Halflife: The half life of oral ixycodone pills is 3.5 to 4 hours . So in 5 halflives, or 17.5 - 20 hours, most of the oxycodone is eliminated. This applies to a single oral dose, not to a patient who has been chronically using the drug.

About 4 hours: Depending on your general health, use of other medications that can affect the way it is metabolized, your level of tolerance and length of time (weeks versus years) that you have been taking it. The greater the length of exposure the less effective, generally speaking, it becomes. Dosing is also crucial to achieve the desired effect.