With the concerns about acetaminophen and ibuprofen and liver effects, is it safer to take aspirin for inflammation? headache? pericarditis?

Pain meds: It depends on what your trying to accomplish by taking these medicines. If you are taking pain meds once a week, anything should work. However, Aspirin taken frequently, can reduce headache and other pains but Aspirin increases bleeding potential and tinnitis, (ringing in the ears). If you are taking a lot of pain meds, contact your physician or pharmacist for knowledgeable info.

Depends: Each choice has benefits & risks. Tylenol (acetaminophen) in appropriate doses is very safe for pain relief, but has no anti-inflammatory effect & can be dangerous with alcohol or overdoses. Ibuprofen is generally safe if not taken on an empty stomach--not generally concerned about liver effects, but can be hard on stomach & kidneys with chronic use. Aspirin may increase bleeding risks. Discuss with your pcp.