A 36-year-old female asked:
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does oxycodone 10/325 have more or less tylenol (acetaminophen) than 10/650 n wats da difference?

2 doctor answers
Dr. Gebrehana Zebro (formerly Woldegiorgis)
31 years experience Internal Medicine
Obviously yes: The 10/650 has double the amount of tylenol (acetaminophen) than the 10/325. I suggest not to take more than 2-3 times a day otherwise , you are putting your liver at significant risk of damage . If you absolutely need opiate medication regularly in frequent interval to control your pain, it would be advisable to give you plain oxycodone with out tylenol (acetaminophen)
Answered on Jul 18, 2019
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Dr. Robert Kent
11 years experience Physical Medicine and Rehabilitation
10/650 has more: The first number in the 10/325 or 10/650 is the oxycodone dose. The second number in that formulation is the amount of tylenol (or acetaminophen). The 10/650 will have twice the tylenol as the 10/325. Some people respond better with more tylenol, but this also limits how often you can take it in a day due to increased chance of liver toxicity. Hope this helps!
Answered on Jun 20, 2016
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