A member asked:

Does oxycodone 10/325 have more or less tylenol (acetaminophen) than 10/650 n wats da difference?

6 doctors weighed in across 2 answers
Dr. Gebrehana Zebro (formerly Woldegiorgis) answered

Specializes in Internal Medicine

Obviously yes: The 10/650 has double the amount of tylenol (acetaminophen) than the 10/325. I suggest not to take more than 2-3 times a day otherwise , you are putting your liver at significant risk of damage . If you absolutely need opiate medication regularly in frequent interval to control your pain, it would be advisable to give you plain oxycodone with out tylenol (acetaminophen)

Answered 7/18/2019


Dr. Robert Kent answered

Specializes in Physical & Rehabilitation Medicine

10/650 has more: The first number in the 10/325 or 10/650 is the oxycodone dose. The second number in that formulation is the amount of tylenol (or acetaminophen). The 10/650 will have twice the tylenol as the 10/325. Some people respond better with more tylenol, but this also limits how often you can take it in a day due to increased chance of liver toxicity. Hope this helps!

Answered 6/20/2016



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