A member asked:

I had a cleft lip and palate. what are my future children's chances of getting it?

8 doctors weighed in across 2 answers

~6%: Parent to child risk can best be calculated with a thorough review of the family tree and input from both sides of the family.A single affected patent will have ~6% risk per pregnancy if the other parent is not affected. Be aware that any pregnancy has some risk of a surprise at dellivery. A consultation with a genetic counselor could review all your risks.

Answered 3/19/2012

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Inheritance CLP: For cleft lip without palate (you-father affected) the risk is 2%. For cleft lip and palate (again-father affected) the risk is 7% without other "syndromes" associated with this. Cleft lip and cleft lip and palate are 2 times more common in males. Isolated cleft palates are 2 times more common in females. Inheritance is "multifactorial.".

Answered 7/5/2012

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