What's your opinion on treating histoplasmosis?

Don't (usually): Histoplasmosis is almost always a self limited disease. While we have excellent drugs to treat it, they should be reserved for people who have symptomatic disease or those with severe immune compromise (chemotherapy, hiv, , transplants or other immunosuppressive treatments). Most histo is only discovered by accident, and in those cases, treatment provides no help and can have side effects.