What leads to diffuse esophageal spasm?

True anomaly: This is a true abnormal condition or physiomechanics of the esophagus -- it is a rare condition-- and what most people experience is not a diffuse esophageal spasm but reflux esophagitis with spasm or cold induced transient esophageal contraction.

Do you have DES?: Spastic motility disorders are defined by esophageal manometry, but the intermittent nature of these abnormalities like DES frequently requires other esophageal tests before starting treatment. Of course, pain of DES can mimic coronary artery disease sufficiently that a cardiac evaluation should first rule out heart & vessel problems. Also, address associated heartburn & irritable bowel syndrome.