Can you mix hydrocodone and tramadol?

I would not: There is no reason to. They are similar. It is not acceptable to use two of the same type. We would rather use different medicine types.

Yes: There is no direct interaction between these tow but the two meds together will provide very potent pain relief and can lead to excessive sedation and slowed breathing. Be especially careful not to drink alcohol when on this mixture. No driving or operating heavy machinery until you are sure that you are overly sedated.