On 50mg zoloft (sertraline) x 15 yrs for pms & menopause emotions; can it reverse its effect after so long?

SSRI effects: Can ssri effects "switch" after years? When the benefits of an ssri or other antidepressant seem to "go away", this usually indicates either (1) that the patient has had a breakthrough depression/anxiety episode or (2) the patient also needs a mood stabilizer added to treatment. Across a life, the body changes in response to ageing changes and to life stressor exposure.Please call your prescriber!