How is lamictal believed to work for seizure disorders? what might it mean if your seizures respond better to lamictal than topamax (topiramate)?

Some thots: Although like many meds in epilepsy, we do not fully understand mechanisms, Lamictal is thought to work by controlling sodium channel functions, and secondarily suppressing excitatory neurotransmitters (glutamate and aspartate). Not surprised of benefit, as Lamictal remains the first choice of epileptologists across the country.

Lamictal: The mechanism of action is related to inactivation of voltage dependent sodium channels. Lamictal reduces the release of glutamate and aspartate, excitatory brain transmitters. An individual's seizure may respond to one medicaition or another depending on unique properties. It does not mean that one antiseizure medication is better than another in general, only personally, .