A member asked:

Symptoms of allergic reaction to antihistmine ?

13 doctors weighed in across 3 answers

Red herring?: It would be exceedingly unusual to have a true allergic reaction to an antihistamine. You'd need a blinded, placebo-controlled challenge to establish a true causal link.

Answered 7/14/2020

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Dr. Peter Kurzweil answered

Specializes in Internal Medicine

That's curious....: Allergic reactions are when the body's immune system detect something that it recognizes as a foreign substance (ingested, contact through skin, food or medicine, or in the case of auto-immure diseases, it's own cells). One reax is to mobilize cells that secrete anti-histamines to fight the allergic reax. So, allergic relax to antihistamine would be very unusual. Let detective doc sort this out.

Answered 12/31/2022

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Dr. Duane Gels answered

Specializes in Allergy and Immunology

Exceptionally rare: Probably never happens; almost alway the antihistamine in question is either inadequate to control the allergy (such as hives, swelling, leading to blood pressure drop) or another cause is found. I would seriously contact an allergist who can methodically evaluation your situation.

Answered 10/18/2019

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