A member asked:

Can lamotrigine cause a rash after being on it a year or so?

12 doctors weighed in across 4 answers

Uncommon, but maybe: Lamotrigine (lamictal) can (rarely) cause serious, even life-threatening, rashes, but these usually occur within 2 to 8 weeks of starting treatment, but very rarely can occur later. Risk of serious (eg stevens johnson syndrome) is roughly 0.8% in kids and 0.3% in adults. If you develop a rash while taking Lamotrigine you should see a doctor to see if the rash can be attributed to something else.

Answered 6/26/2014

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Drug reactions: While most medication reactions will occur fairly early in the course of treatment an allergic reaction can happen at any point in therapy. Any suspicious reaction should be evaluated.

Answered 1/15/2018

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Dr. Ralph Morgan Lewis answered

Specializes in Family Medicine

Lamotrigine rash: Apparently most rashes associated with this drug occur within 2 - 8 weeks after starting it. (note these rashes may be life-threatening: stevens-johnson-syndrome/toxic epidermal necrolysis and drug reaction with eosinophilia and systemic symptoms (dress)). One source states that stopping the drug at any point & restarting at the same dose can trigger a rash. So, it's possible, even after a year.

Answered 10/3/2016

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Dr. Peter Kurzweil answered

Specializes in Internal Medicine

YES, STOP NOW.: Lamotrigine (brand lamictal) is used for certain seizure disorders, bipolar disease, part of pain management and other off-label uses. You can develop a rash any time after starting the drug. And it can be very serious, even a life-threatening disease called steven-johnson syndrome. Always call your physician or the specialist who prescribed a drug that u think ur getting a rash from.

Answered 12/9/2022

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