I am obese and am trying to lose weight following slimmin world plan but not seeing big losses, could taking sertraline be affecting my weight losses?

Metabolic syndrome: What you have is called the "metabolic syndrome". It would be rare for zoloft (sertraline) to interfere with weight loss, although a few cases of weight gain on zoloft (sertraline) after six months or more of treatment are generally seen by most seasoned psychiatrists. With HTN and venous stasis you might consider one of the available gastric bariatric procedures. Sleep apnea can cause obesity and HTN also.