Is there an interaction between flexeril (cyclobenzaprine hcl) & tramadol? my doctor stopped it after 3 months, saying there was an interaction, but i had amazing relief.

CNS: Only 2 major concerns: 1) general impact on level of consciousness making you tired or sleepy, less coordinated, thereby affecting your function including driving. Timing of when you take each med affects this, but after 3 months, you should notice if this concern is significant. 2) lower seizure threshold. Unless you have a seizure disorder, family history, or drink alcohol, this is minor.

Yes: Depression, psychomotor impairment and possibly seizures.