A member asked:

Are tramadol, flexeril (cyclobenzaprine hcl) and promethazine safe for someone with seizures?

3 doctors weighed in across 2 answers

Risky: Tramadol, Flexeril (cyclobenzaprine hcl) & Promethazine are potentially epileptogenic, lowering seizure threshold. Degree of risk must be balanced with benefits. Certainly a poorly controlled seizure disorder should lead to a different choice of drugs.

Answered 6/30/2014

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Dr. Syed H. Sajid answered

Specializes in General Adult Psychiatry; Child & Adolescent Psychiatry ( 1 yr. Fellowship), sees all types of patients for Medication Management from ages 6-99yo

Not safe: Tramadol, flexaril and Promethazine are not safe for someone with seizures. All of them may increase the risk o seizures.

Answered 6/19/2015

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