Which ibs medication for cramps and bloatingis considered the best?

Depends...: It depends what variant of ibs you have. If due to sibo (small intestinal bacterial overgrowth) then antibiotics like xifaxan (rifaximin) may help. If you're female with severe diarrhea-associated ibs, consider Lotronex under the prescriber's program. For constipation-variant disease, Amitiza & Linzess are effective & well-tolerated. Frequency, timing, & duration of symptoms? Bleeding? Sure you have ibs?