What is the best way to cure blemish overnight?

Kenalog (triamcinolone): See if your local dermatologist can fit you in to their schedule for a quick intralesional kenalog (triamcinolone) injection.

Acne treatment fast: Acne can be prevented or minimized by using a gentle cleanser twice daily, such as over the counter benzoyl peroxide or salicylic acid products, or prescription medications including topical cream with or without oral medications. Don't pick! Aside from applying cool compresses to reduced redness, symptoms will likely not completely improve for a few days.