A 23-year-old female asked:
is it possible to build a tolerance to enbrel (etanercept) and how til it could happen. i'm haven't been on it a year and the effects are decreasing ?
2 doctor answers • 3 doctors weighed in
Rheumatology 52 years experience
Yes: Do you take Methotrexate as well? Some individuals do develop antibodies to Enbrel (etanercept) over time which can limit its effectiveness. The concurrent use of Methotrexate can reduce that risk. Also, the disease can just become more active and the Enbrel (etanercept) becomes less able to control it. Do not worry. There are many very effective options. Talk to your rheumatologist.
4966 viewsReviewed >2 years ago
Rheumatology 21 years experience
See below: Tolerance can occur as a result of anti-chimeric antibodies which is where your body makes antibodies to enbrel (etanercept). It is less apt to occur if you are on methotrexate.
4964 viewsReviewed >2 years ago
Last updated Dec 11, 2018
Connect with a U.S. board-certified doctor by text or video anytime, anywhere.
$15 per month
Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.