Can frequent diarrhea prevent the absorption of meds? am on janumet xr, (sitagliptin and metformin) have diarrhea multiple times a day, regardless of diet changes.

Yes: The diarrhea is not the problem. Whatever is causing you to lose a lot of water in your intestinal track may be interfering with the full absorption of some medications. Continuous diarrhea may cause a life-threatening condition as you lose important electrolytes in addition to water. See a doctor to evaluate the cause of diarrhea, which may include the medication you are taking.