Never heard of this: However it is a CNS stimulant thought to antagonize Adenosine a1 and a2 receptors[methylxanthine].. Metabolized in the liver via cyp450 1a2 substrate with active metabolites. Thus it could interact with supplements like yohimbine as well as prescription medications causing anxiety which may be experienced as 'horney'. If mixed with cannabinoids i suppose this could be one 'adverse' reaction !
Answered 10/4/2016
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