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A 25-year-old male asked:

How does geodon (ziprasidone) work? it acts on many receptors and transporters..

1 doctor answer1 doctor weighed in
Dr. Alan Ali
Dr. Alan Alianswered
Psychiatry 32 years experience
Geodon (ziprasidone): It has high affinity for dopamine, serotonin & alpha-1 adrenergic receptors, & moderate affinity for histamine h-1 receptors. It also inhibits synaptic reuptake of serotonin & norepinephrine. Blockage of d2 & 5-ht2a receptors attributes to its effects on positive psychotic symptoms. Inhibition of reuptake of serotonin & norepinephrine attributes to its effect on alleviating negative symptoms.

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Last updated Jul 1, 2013

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