What is primary empty sella syndrome?

No pituitary gland: Empty sella syndrome is a condition where the pituitary gland is either absent or non-visible on standard imaging. Primary denotes that it's something you were born with. In general, primary empty sella syndrome presents with no symptoms as there is generally enough pituitary gland to support endocrine function.

MRI observation: Primary empty sella syndrome is a description given when a pituitary gland (which normally sits in a region called the "sella turcica") cannot be visualized on mri. This can be because the pituitary glad is small or flattened for some reason. Often no symptoms will be present, but can include headache, impotence, or nipple discharge due to changes in the hormones normally produced by the gland.