I am wondering why my norco (hydrocodone and acetaminophen) does not work first thing in the morning. i take 2, 10/325's and 1, 5/325. i have been on it for 5 months. ?

See below: Once pain is active and causing you trouble it takes time to get it back under control. So your morning dose is taking time to kick in and get control. You are probably building up a tolerance to your medication as well which just means it is harder to get the pain under control. Talk to your md about other alternatives to narcotics.

Drug tolerance: Norco (hydrocodone and acetaminophen) belongs to the opioid family of medications. In some patients, over time, these medications lose their efficacy, a process termed tolerance. Tolerance may be the reason that Norco (hydrocodone and acetaminophen) is less effective in treating your pain. You would benefit from a thorough history and physical exam by a pain management specialist to determine whether your underlying pain condition has worsened.