Should i experience weight loss, a since of fullness, and loss of appetite while having mono?

Yes. : Mono is often accompanied by inflammation of the liver and enlargement of the spleen, these combine to give you a feeling of being full very quickly, and to dec your appetite. Your liver functions should be periodically checked by your doctor to make sure all returns to normal, and to let you know when you are safe to resume normal activities such as contact sports and alcohol consumption.