A member asked:

What is snri and how does it work? what drugs are in this class? is tramadol an snri? what is seratonin syndrome? do these treat depression and pain?

A doctor has provided 1 answer
Dr. Pamela Pappas answered

Specializes in Psychiatry

SNRI: Snri = serotonin norepinephrine reuptake inhibitor. Effexor, pristiq, meridia, savella (milnacipran), (milnacipran) and Cymbalta are in this class. Tramadol is not. When serotonin and norepinephrine are not taken back up into the neuron, they are more available in the synaptic cleft between neurons. Cymbalta & savella (milnacipran) treat fibro pain; the others more for depression. Cymbalta can treat depression; savella (milnacipran) perhaps less so.

Answered 12/19/2014

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