Zofran (ondansetron) for nausea: If you stop a medicine for nausea, most likely you will experience a rebound effect after stopping the medication. Zofran (ondansetron) does not produce tolerance, therefore there will be not discontinuation syndrome or physical withdrawal if not taken anymore. Hopefully the cause for the nausea has disappeared and stopping zofran (ondansetron) will not cause any problems.
Answered 11/13/2017
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