Mother has breast cancer at 53, her father had colon at 87, her paternal uncle had aml at 65 and her paternal cousin aml at 50. hereditary?

Posible: If no other members of your family has breast or colon cancers then your parents has disease at random , not genetic etiology. Your uncle family has acute myeloid leukemia in two members in two generations , possibly genetic ( hereditary ) , may be have cebpa mutation or some thing else , you have to speak to the oncologist with patients permission and may need investigation.

Likely no: Most of your family members are developing their cancers later in life, and there is not an obvious pattern of inheritance from this limited amount of info. I'd talk about this with your doc and do a quick pedigree analysis. Modern techniques are revealing correlations that we couldn't see in the past. So a good history can be helpful to tease out any possible association.

Possibly: Rare genetic syndrome called li fraumeni. But could be just sporadic. I think it would be reasonable to do two things: 1) have a CBC done 2) consider meeting with a genetic counselor. Hope this helps.