A 47-year-old member asked:
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what causes monoclonal paraproteinemia?

1 doctor answer
Dr. Sewa Legha
49 years experience Medical Oncology
Excess of Plasma cel: Plasma cells in our bone marrow make antibodies. Sometimes they become overly active/reactive and produce abnormal proteins called paraproteins. Most such protein production is benign and not uncommon in older folks. Sometimes it is excessive(more than 1gram/day) then we get concerned about a condition called multiple myeloma (paraproteins over 3 grams).
Answered on Nov 12, 2017

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Yes in most ways: Myeloma is one of the differential diagnosis, the other condition is called mgus
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