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A member asked:
Howquickly does the effectiveness of vicodin decrease?
A doctor has provided 1 answer
Vicodin : Onset: ~20min; duration of action ~4 -8hrs (1/2 life elimination ~4hrs). Effects can be variable depending on liver health, rate of metabolism, rate of excretion (gi, kidney), drug-drug interaction & whether or not opiate naïve. Genetic variations in cyp2d6 (poor or extensive metabolizers) may also influence effect. "effectiveness" diminishes rapidly if you're asking about its euphoric effects.
Answered 1/15/2015
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