Sharp in in stomach after drinking alcohol night before?

Irritation: Alcoholis rapidly metabolized in the body, and generates reactive oxygen species. As a pro-oxidant, it causes oxidative damage to the cells and tissues in the GI tract. The stomach and the intestines have a single layer of cells lining its inner side, which normally provides a barrier. When this barrier is disrupted, inflammation can occur, leading to stomach pain. Gastritis, pancreatitis, etc.