A 41-year-old female asked:
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can spironolactone cause melasma or make it worse?

1 doctor answer
Dr. David Sneid
40 years experience Endocrinology
Not known: Melasma can worsen due to estrogen, progesterone, sun exposure, etc. Spironolactone can lower testosterone, so in theory it could increase estrogen slightly, but have never seen it described as causing or worsening melasma.
Answered on Oct 26, 2018
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