What should i do to make sure that there are no bed bugs in our hotel room?

Bed Bugs: Inspect your sheets and folds, crevices, linings and all sides of your mattress. Do not leave any crevice uninspected. Because bed bugs are so small and have flat bodies, they can easily hide in tight spaces. Look for stains from bed bug droppings on your mattress. Bed bugs have a tendency of living communally and will often leave fecal evidence.

Tell Tale Signs: Agree w dr fisher. Here are some tell tale signs of bedbugs. First you may notice blood smears on bedding . Remember that the blood smears usually turn black over time. Second you may see amber colored “shells” which occurs when the bed bug sheds it's exoskeleton. A third sign of infestation is bug feces on sheets (brown- black dots). The fourth sign can occur with a heavy infestation – an odor.