I understand that chewing tobacco is a cause of mouth cancer, but can use of methamphetamine also cause cancer in the mouth?

Short answer is yes.: Any irritant consistently applied to tissue can cause premalignant lesions that can later turn malignant. If you are abusing methamphetamines, then other systemic health problems may also ensue that are just as serious! please call your physician, dentist or drug help line for help as soon as possible! don't ruin your life!

No but: Using methamphetamine can cause severe tooth decay, periodontitis, and the loss of many teeth, also known as “meth mouth.”. While meth does not cause cancer per se, many activities related to meth (smoking, marijuana) do contribute to oral cancer.