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What exactly does grade 1, 2, 3, 4 of the tumor mean in clear cell renal cell carcinoma?

6 doctors weighed in across 2 answers

How cells look: Grading refers to how closely the cancer cells resemble normal kidney cells. Cells that are more abnormal (ie higher grade) are associated with a worse prognosis.

Answered 9/7/2013

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Cell size and shape: When a clear cell renal cell carcinoma is removed, the cells are examined under the microscope by a pathologist. Grade 1 means that the nuclei (which contain cells' dna) are very small and often correlates with a good prognosis. Grade 4 means that the nuclei are very large and abnormal and often suggests a worse prognosis. Grades 2-3 are in between. Grade 2 is probably the most common.

Answered 11/28/2017

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