A member asked:

I want to switch back to lexapro (escitalopram) from zoloft. is that ok?

14 doctors weighed in across 7 answers
Dr. Gregory Hines answered

Specializes in Family Medicine

They are similar: Both are ssri type antidepressants, and can be substituted for each other. However, Lexapro (escitalopram) is a second generation antidepressant, and is often more effective than your zoloft.

Answered 5/8/2016

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Yes: You may be able to switch back to zoloft without any problems. However, each medication works differently in each individual, so even though Lexapro (escitalopram) and zoloft are in the same class of medications you may have more side effects or a better response with one versus the other.

Answered 5/8/2016

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No problem: They are both ssris--your doc should make the final decision.

Answered 11/27/2017

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Generally yes: Obviously you should talk to your prescribing doc, don't switch behind their back. They need to know what you're taking, & may have other options to suggest. But yes, it's usually safe & easy to switch between Lexapro (escitalopram) & zoloft. Note that the dosages (mg) are different. Also, zoloft is available as generic while Lexapro (escitalopram) isn't, so Lexapro (escitalopram) costs more & insurance may not cover it.

Answered 5/13/2019

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Dr. Kevin Nasky answered

Specializes in Psychiatry

Yes.: As you probably know, both Lexapro (escitalopram) and zoloft are selective serotonin reuptake inhibitors, so switching is not difficult as you're switching within a class. Secondly, you have already demonstrated that you've both tolerated and responded to zoloft, which should make both you and your doc comfortable. This may require a cross-taper, but your doc will have to decide.

Answered 12/23/2018

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Generally no problem: It generally is not a problem switching from Lexapro (escitalopram) to zoloft, since they are in the same class of antidepressant medications. However, there are a number of considerations (e.g. What dosage of Lexapro (escitalopram) are you on; what dosage of zoloft are you hoping to achieve; how fast can the switch be made) that should be discussed with your doctor before making the switch.

Answered 9/28/2016

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Yes: There is no risk. Zoloft (sertraline) is also great antidepressant.

Answered 5/7/2016

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