A member asked:

What is an effective treatment for hppd- hallucinagen persisting perceptual disorder?

26 doctors weighed in across 5 answers

Limited data: Benzodiazepines have been used, and some anti-epileptics may be helpful as well (e.g., keppra). Apparently, antipsychotics are not so helpful, and may aggravate symptoms. Of course, patients need good stress management, adequate sleep and proper diet. And they should avoid recreational drugs in general.

Answered 11/27/2017

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Dr. Ravi Chand answered

Specializes in Psychiatry

HPPD: Usually its not treatable, hope is there is no permanent neurologic damage. Supportive treatment, relaxation, good sleep, benzodiazepines, Keppra (levetiracetam) or levaciteram, tolcapone and levocarb may help.

Answered 10/6/2017

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I agree with my: Colleagues answer, but be carefully with keppra (levetiracetam). I was given it to prevent seizures and it made me hallucinate horrible things and threw me into a deep black hole suicidal depression. I don't know that i would want to give it to someone who is already hallucinating. Those were the three worst days of my life.

Answered 10/2/2017

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Dr. Ruth Seaman answered

Specializes in Psychiatry

Difficult problem: I've encountered this phenom more than I'd like to. Its been difficult to obtain great responses. I do use low dose DA blockers / atypicals, but results vary. Based on co-morbid Sxs, AED's can be reasonable as well. Verdict is out yet on central Alpha antagonists (doxazosin/prazosin)

Answered 9/23/2017

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Dr. Eric Weisman answered

Specializes in Neurology

The modal HPPD: patient turns out to have complex partial epilepsy. Seizure activity that starts or spreads to homotypic visual or auditory association cortex gives rise to formed visual and auditiory hallucinations. Seizures activating heteromodal association cortex tend to give more complicated seizure types. Seizures arising from primary sensory cortex give unformed hallucinations that may evolve to formed.

Answered 10/9/2017

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