What kind of counter medicine is effective for lupus?

Aspirin: Aspirin and nonsteroidals may help with some of the discomfort.

Some helpful hints: Avoid sunlight: use sunscreen with spf of 55 or higher. Balanced diet, supplement vit-d and calcium, exercise, stop smoking, avoid drugs containing sulfa(trimethoprim-sulfamethoxazole, sulfadiazine etc), avoid pregnancy during active disease. Regarding your question, therapy wise except nsaids like advil, aleve, (naproxen) for pain and vitamin supplements there is nothing over the counter to help you.