Could ppi help improve bowel inflammation?

PPIs probably won't help. They reduce stomach acid, which is unlikely to help lower intestinal inflammation or symptoms. Have you been diagnosed with inflammatory bowel disease, like Crohn's disease, ulcerative colitis, or diverticulitis? If you have diarrhea, cramps or other symptoms that suggest bowel inflammation, see a doctor -- don't try to treat yourself with a PPI or any other medication.