My wife is pregnant first trimester and may have a yeast infection. are homeopathic creams like yeast-gard topical gel (available at cvs) safe for use during pregnancy? are there any other natural remedies? thank you?

"Safe" is relative in the first trimester (in particular) as we can't prove a negative and it is difficult to show harm except in the most obvious cases. It is best to avoid using anything non-essential. Also, just because something is "natural" doesn't mean it's safer. Your wife should discuss any concerns or problems with her obstetrician or midwife before taking or using anything.