Is it safe to take flexeril at night then take 30mg of cymbalta (duloxetine) in the daytime?

I consider flexeril to be a distant relative of tranquilizers like ativan& valium and taking it with cymbalta on board isn't advisable as this combination can cause dizziness & the rare serotonin syndrome,a dangerous condition. Your physician or pharmacist can advise you further.

Agree with Dr. Colantino, as the described mix can eventuate in additive side effects. Would definitely avoid driving if you are taking both regularly. You need to discuss this in detail with your prescribing doctor.