Reactions that are localized to one area/region are usually due to a contact trigger rather than a drug. Something like residual sizing in a new article of clothing covering the trunk would be an example. That said, people can develop an allergy to any material they once did not. Antihistamines like Benadryl/Zyrtec can help with hives or itching but not cancel the allergy.
Answered 1/26/2023
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