Can taking a corticosteroid for a long time cause psychosis and irritability/rage?

Chronic steroid usage can result in many problems including metabolic changes and osteoporosis. Steroid "madness" or psychosis is uncommon when administered once daily or every other day, but is still possible at high dosing. This can be confusing as an underlying brain inflammation associated with the condition for which the steroids are employed may be an alternative explanation.