A member asked:

Ive read that kshv transmission between sero discordant heterosexual couples is rare and difficult, including by saliva/kissing and oral sex. one report read that its reliant on the susceptible person having a lowered immune system. is there evidence?

2 doctors weighed in across 2 answers
Dr. Jay Park answered

Human Herpesvirus 8 (HHV-8) is the causative agent associated with Kaposi sarcoma (KS). HHV-8 infection among immunocompromised individuals. e.g., HIV infected (poorly controlled), organ transplant recipients, and men who have sex with men tends to have more severe manifestations including KS.

Answered 9/28/2022

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There is truth in your statement, Why some people get it and others dont is dependent on the immune system

Answered 9/28/2022

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