What would cause deep depression (and sometimes dry eyes) in a woman in her 40s after masturbation? this started happening a few years ago. it feels like something hormonal. sometimes it is hard to orgasm unless omega 3 fish oil is taken. thank you?

It is not feasible to provide an opinion without additional history, physical examination may be some tests. It would be prudent to see your doctor to see if you may be depressed. Depression is treatable. Counter-intuitive as it may seem, exercise may help. Start with low intensity exercise such as walking and gradually increase the intensity as tolerated. Drink more water. Wish you good health!